TaRGET II Consortium

Purpose

The TaRGET (Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription) Program is a research consortium funded by the National Institute of Environmental Health Sciences (NIEHS). The goal of the collaboration is to address the role of environmental exposures in disease pathogenesis as a function of epigenome perturbation, including understanding the environmental control of epigenetic mechanisms and assessing the utility of surrogate tissue analysis in mouse models of disease-relevant environmental exposures.

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Newsfeed:

  • May 4, 2018: The RNA-seq pipeline is now available on the Software page. The ATAC-seq QC standards are now available on the wiki.
  • March 6, 2018: The TaRGET II white paper, The NIEHS TaRGET II Consortium and environmental epigenomics, was published today in Nature Biotechnology. It is available on the Nature Biotechnology website and on the Publications page.
  • The policies of the TaRGET II consortium have been finalized, and the handbook is available to the consortium here.
  • Standard Operating Procedures finalized by the Methods Working Group are available to the consortium here.
  • December 12-13, 2017: The TaRGET II consortium met in Houston, Texas (presentations).
  • Software developed by the consortium, including the ATAC-seq QC pipeline in docker format, are available on the Software page.
  • Aug 9, 2017: The tutorial for batch upload of metadata is online now.
  • Jun 7-8, 2017: The TaRGET II consortium met at NIEHS (minutes).
  • Dec 5, 2016: The TaRGET II consortium meeting was held at NIEHS (minutes).
  • Oct 11, 2016: The tutorial for uploading data is online now.
  • May 2-4, 2016: The kick-off meeting of the TaRGET II consortium was held at NIEHS.